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KMID : 1137820190400020039
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의공학회지
2019 Volume.40 No. 2 p.39 ~ p.47
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Effects of Anticancer Drug Delivery based on Microbubble and Microbubble-Nanoparticle Complex using Low-Intensity Focused Ultrasound in Breast Cancer Animal Model
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Baek Hee-Gyu
Ha Shin-Woo
Huh Hyung-Kyu
Jung Byeong-Jin
Han Mun
Moon Hyung-Won
Kim Sang-Kyun
Lee Hak-Jong
Park Ju-Young
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Abstract
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Ultrasound sonication along with microbubble (MB) could enhance drug delivery to promote the absorption of anticancer drugs into cancers in a noninvasive and targeted manners. In this study, we verify the acute drug delivery enhancement (within an hour) of two representative focused ultrasound driven drug delivery enhancement methods (MB and Doxorubicin-coated Nanoparticle complex (MB-NP) based). Experiments were conducted using in vivo mouse model with MDA-MB-231 breast cancer cell line. Ultrasound generated by single-element 1 MHz focused ultrasound transducer was delivered in pulsed sonication consisted of 0.125 msec bursts at a pulse repetition frequency of 2 Hz for 20 seconds without a significant increase in local temperature (less than 0.1oC) or hemorrhage. Doxorubicin concentrations in tumors were improved by 1.97 times in the case of MB-NP, and 1.98 times by using Doxorubicin and MB separately. These results indicate anticancer drug delivery based on MB and MB-NP can sig-nificantly improve the effect of anticancer drugs delivered to tumors in a short time period by using low-intensity focused ultrasound.
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KEYWORD
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Breast cancer, Anticancer drug delivery, Focused ultrasound, Microbubble, Microbubble- Nanoparticle complex
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